Prison Break is an American serial drama television series created by Paul Scheuring, that was broadcast on the Fox Broadcasting Company from 2005 until 2009. The series revolves around two brothers; one has been sentenced to death for a crime he did not commit, and the other devises an elaborate plan to help his brother escape prison. The series was produced by Adelstein-Parouse Productions, in association with Original Television and 20th Century Fox Television. Along with creator Paul Scheuring, the series is executive produced by Matt Olmstead, Kevin Hooks, Marty Adelstein, Dawn Parouse, Neal H. Moritz, and Brett Ratner who directed the pilot episode. The series' theme music, composed by Ramin Djawadi, was nominated for a Primetime Emmy Award in 2006.

The series was originally turned down by Fox in 2003, which was concerned about the long-term prospects of such a series. Following the popularity of serialized prime time television series Lost and 24, Fox decided to back production in 2004. The first season received generally positive reviews, and performed well in the ratings. The first season was originally planned for a 13-episode run, but was extended to include an extra nine episodes due to its popularity. Prison Break has been nominated for several industry awards, and won the 2006 People's Choice Award for Favorite New TV Drama and was nominated for the 2005 Golden Globe Award for Best Television Series Drama. All four seasons have been released on DVD, while the first and third seasons have also been released on Blu-ray Disc. The series has been aired internationally.

The success of the series has inspired short videos for mobile phones, several official tie-ins in print and on the Internet, as well as a video game. A spin-off series, Prison Break: Proof of Innocence, was produced exclusively for mobile phones. The series has spawned an official magazine and a tie-in novel. The fourth season of Prison Break returned from its mid-season break in a new timeslot on April 17, 2009 for the series' last six episodes. Two additional episodes, titled "The Old Ball and Chain" and "Free" were produced, and were later transformed into a standalone feature, titled The Final Break. The events of this feature take place before the last scene of the series finale, and are intended to wrap up unfinished plotlines. The feature was released on DVD and Blu-ray July 21, 2009.

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